NAD+
Research Use Only · Not for Human Consumption
Nicotinamide adenine dinucleotide, a coenzyme naturally present in every living cell
Nicotinamide adenine dinucleotide · 500 mg lyophilized research vial
Chemistry
| CAS# | Formula | Molar Mass |
|---|---|---|
| CAS Number: 53-84-9 | Molecular Formula: C21H27N7O14P2 | Molar Mass: 663.4 g/mol |
What is NAD+?
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme that has been characterized in biochemical research since the early 1900s. This material is supplied in lyophilized form for preclinical research examining NAD+-dependent enzymatic pathways, including sirtuin deacetylation, PARP-mediated reactions, and mitochondrial redox chemistry.
NAD+ was first identified in 1906 by Arthur Harden and William John Young while studying fermentation in yeast extracts. They observed that adding boiled yeast extract to unboiled extract altered the rate of fermentation—the heat-stable factor they characterized was later recognized as NAD+.
The molecule's role in metabolism was elaborated over the following decades. Hans von Euler-Chelpin received the 1929 Nobel Prize for elucidating NAD's structure and function. NAD+ participates in over 500 enzymatic reactions and serves as a cofactor for enzymes that transfer electrons during cellular respiration and related biochemical processes.
In the early 2000s, published research characterized NAD+ as a required substrate for sirtuin enzymes, a family of deacetylases described in multiple model organisms. Subsequent preclinical research has examined age-associated changes in NAD+ levels and the enzymatic pathways that consume and regenerate it. This product is intended for research use only.
How should NAD+ be stored?
Peptide Foundry research peptides are supplied lyophilized (freeze-dried). Keep sealed vials cool, dry, and protected from light until reconstitution.
After reconstitution, refrigerate prepared solutions and use sterile technique. For general laboratory diluent and handling notes, see lyophilized peptide reconstitution.
Certificate of Analysis
NAD+ 500mg lot FO901 was tested by Freedom Diagnostics for identity, purity, elemental impurities, endotoxin, and microbial contamination. The original certificate is below.
NAD+ · 500mg
Purity · HPLC-UV
99.93% purity
Purity measured by HPLC-UV; identity confirmed by LC-MS, as reported for lot FO901.
Every test on this certificate
COA documents are updated with each new batch. Contact support for batch-specific documentation.
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Further reading
References
- Verdin E. NAD+ in aging, metabolism, and neurodegeneration. Science. 2015;350(6265):1208-1213. PubMed: 26785480
- Imai S, Guarente L. NAD+ and sirtuins in aging and disease. Trends in Cell Biology. 2014;24(8):464-471. PubMed: 24786309
- Yoshino J, et al. NAD+ intermediates: The biology and therapeutic potential of NMN and NR. Cell Metabolism. 2018;27(3):513-528. PubMed: 29249689
