Epithalon Research Peptide: Naming, CAS & What a COA Should Show

Read Epithalon lot EPI50312 COAs: separate purity and endotoxin results, laboratory lookup codes, and links to current product specifications. Research use only.

Last reviewed 1 October 2026 · For research use only

CAS Number

307297-39-8

Molecular Formula

C₁₄H₂₂N₄O₉ C14H22N4O9

Molar Mass

390.35 g/mol

Epithalon, also spelled Epitalon, is the synthetic tetrapeptide Ala-Glu-Asp-Gly (AEDG). This guide explains its catalog identity and how to check the published documents for a specific research lot.

Looking for a certificate? Review the two reports for lot EPI50312, including their separate results and laboratory search codes. For current availability and specifications, view the Epithalon research product. All materials are for laboratory research only.

Key points

• Epithalon = synthetic tetrapeptide Ala-Glu-Asp-Gly (AEDG); supplied as lyophilized research material (white powder on current Peptide Foundry lot documents).
• Peptide Foundry catalog anchors (live PDP): CAS 307297-39-8, formula C₁₄H₂₂N₄O₉, molar mass 390.35 g/mol, PubChem 219042 — match certificate fields to these claims.
• Epithalon / Epitalon / Epithalone are common spelling variants of the same synthetic tetrapeptide when CAS, formula, and sequence match; epithalamin is a pineal extract fraction historically studied — not certificate proof by itself.
• Demand a lot-matched COA: HPLC purity with method when stated, MS identity, named laboratory, and preferably independent portal verify; treat “amidate” listings as a terminus-form check against formula and mass.
• Research use only — not for human or veterinary use.

What is Epithalon?

Epithalon is a four-residue synthetic peptide: alanine–glutamic acid–aspartic acid–glycine (AEDG). Residue count is four (tetrapeptide). The research material on this page is the defined synthetic sequence, not a crude tissue extract.

A short historical note anchors naming only. Work associated with Khavinson and colleagues in the St. Petersburg Institute tradition described pineal peptide fractions (epithalamin), then studied defined synthetic sequences related to that line. That is origin history — not a product claim, not a catalogue mechanism story, and not registry proof.

Physical form on research listings is lyophilized solid. Peptide Foundry’s current lot documents describe white lyophilized powder under SKU PF-EPITHALON at a 50 mg size option. Appearance is a handling observation — not a purity proof and not a substitute for HPLC or MS identity.

Market aliases include Epithalon, Epitalon, Epithalone, AEDG, and informal “epi” shorthand (including “epi 50 peptide”). Aliases help search; they are not identity proof until you have CAS, formula, molar mass, sequence, and a lot-matched certificate.

Naming literacy: Epithalon, Epitalon, epithalamin, and amidate forms

Spelling variants

Epithalon, Epitalon, and Epithalone are the spelling variants you will see most often on research catalogues. When CAS 307297-39-8, formula C₁₄H₂₂N₄O₉, molar mass near 390.35 g/mol, and sequence Ala-Glu-Asp-Gly all agree, treat those spellings as market orthography for the same synthetic tetrapeptide. Peptide Foundry’s primary spelling is Epithalon; Epitalon is acknowledged because many searchers and papers use that form. Prefer registry fields over orthography debates.

Epithalamin extract vs synthetic AEDG

Epithalamin in historical literature typically refers to a pineal gland extract fraction — a complex material class studied as a fraction, not as a single four-residue synthetic. Epithalon is the synthetic Ala-Glu-Asp-Gly tetrapeptide designed as a defined research compound related to that research tradition.

Buyer checklist when a listing leans on pineal or “epithalamin” branding:

• Does the COA list sequence Ala-Glu-Asp-Gly?
• Does it publish CAS 307297-39-8 with formula C₁₄H₂₂N₄O₉ and mass near 390.35 g/mol?
• Does identity language (MS / HPLC) describe the tetrapeptide, not only an extract brand name?

Extract branding alone is not certificate proof. Origin history explains why both terms appear in literature indexes; it does not authorize consumer endocrine framing on a research catalogue page.

Free acid vs amidate (sourcing check)

Some vendors list Na-Epithalon-NH₂, C-terminal amide, or “epithalon amidate” forms. An amidated C-terminus changes formula and mass relative to the free-acid tetrapeptide even when sellers reuse the same marketing name or, in some cases, cite the same CAS string.

Peptide Foundry publishes the free-acid formula C₁₄H₂₂N₄O₉ and molar mass 390.35 g/mol. At publish time Peptide Foundry does not list a separate amidate SKU. Queries such as “epithalon amidate coa” are answered here as literacy: read terminus form, formula, and mass on the certificate, then decide whether the vial matches the vendor’s published anchors.

Practical rule: match terminus form + formula + molar mass + sequence on the lot COA to the vendor’s chemistry table. Do not assume every “Epithalon” label is the free-acid form Peptide Foundry publishes, and do not invent a universal second CAS “winner” for amidate listings. That is a chemical-identity check for purchasing and documentation — keep it there.

Chemical identity anchors

Peptide Foundry publishes a fixed identity set for single-vial Epithalon. The values below match the live catalog chemistry table at the time of writing. Confirm against the current product page if a lot or chemistry block rotates after publish.

Sequence and composition

Sequence: Ala-Glu-Asp-Gly (L-alanyl-L-glutamyl-L-aspartyl-glycine). Residue count: 4 (tetrapeptide). SKU PF-EPITHALON; size option on the live listing at publish time: 50 mg lyophilized.

CAS, formula, and molar mass

Market pages sometimes round mass to 390.3 Da, omit PubChem, or recycle CAS strings across terminus forms. The practical rule is: match the vendor’s stated CAS + formula + molar mass + sequence to the lot COA, then prefer orthogonal identity (MS) over the nickname alone.

Epithalon COA: a worked example for lot EPI50312

The published documentation for Epithalon 50 mg lot EPI50312 consists of two separate Freedom Diagnostics reports: a purity and identity report dated March 15, 2026, and an endotoxin report dated April 11, 2026. Match each report to the lot on your vial. This is a documented example, not a guarantee that a future order will contain this lot.

Purity, identity and measured content

Read the EPI50312 purity and identity COA (PDF). The report identifies the material as Epithalon 50 mg and uses the spelling Epitalon in its identity field.

The report states that its chemical analysis used HPLC with UV detection coupled with mass spectrometry. The purity percentage and measured content are different results: 99.29% is the reported purity, while 55.94 mg is the reported net peptide content of the tested sample. Neither figure changes the product’s labeled 50 mg size.

A separate endotoxin report

Read the EPI50312 endotoxin report (PDF). It names Epitalon 50 mg and the same lot, but has its own accession number, search code and report date.

The report records two passing endotoxin replicates and refers to USP <85> and USP <161>. It does not display a numeric endotoxin concentration or threshold. Do not convert “Pass” into a made-up EU/mg result, a sterility result, or a statement that the material is suitable for human or animal use.

How to look up these reports at the laboratory

1. Open the Freedom Diagnostics COA lookup.
2. Use the report’s printed search code: Pept2603130183 for purity and identity, or Pept2604090025 for endotoxin. The laboratory also offers accession-number and company-name search.
3. Compare the returned document’s client, product, lot, accession number and reported date with the PDF and your vial. A matching product name alone is insufficient.

If a report cannot be retrieved or the fields do not match, ask the laboratory or Peptide Foundry support to resolve it before relying on that document. These links provide the lookup route; opening this guide does not independently authenticate a certificate.

What to check for another lot

Use the current Epithalon specifications and available COAs for the product being offered. Check the vial lot, report date, named laboratory, methods and actual results. Do not apply EPI50312’s figures to another lot or assume that another chemical form has the same report. See how to read a peptide COA for the broader verification workflow.

The PDFs document the submitted samples and stated analyses. They do not establish every catalog identity field, every possible contaminant test, or suitability for clinical use. Keep the catalog identity table separate from what each report actually prints.

Pathway-class literacy (preclinical / in vitro only)

Mechanism language is useful here only as classification of experimental systems in published literature. It does not establish catalogue-product outcomes in people, and it does not convert a citation into a certificate.

Keep pathway class attached to the source paper and the experimental system. Identity remains an analytical question answered by CAS, formula, sequence, and the lot COA.

Storage and laboratory records

Follow the current product storage guidance and your institution’s validated procedures. Keep the vial lot number with your laboratory records and the matching certificates. The two reports discussed above are analytical documents; they do not establish a storage lifetime or a reconstituted-solution protocol.

Common questions

Is Epithalon the same as Epitalon?

As market spelling variants for the synthetic AEDG tetrapeptide — yes, when CAS, formula, molar mass, and sequence match. Peptide Foundry catalogs the material as Epithalon. Prefer registry fields over orthography debates.

Is Epithalon the same as epithalamin?

No. Epithalamin typically names a pineal extract fraction in historical literature. Epithalon is the synthetic Ala-Glu-Asp-Gly tetrapeptide. Match sequence, CAS, formula, and the lot certificate — not extract branding alone.

What about “epithalon amidate”?

Other vendors may offer C-terminal amide or Na-Epithalon-NH₂ forms. Those are different terminus presentations. Peptide Foundry publishes free-acid C₁₄H₂₂N₄O₉ / 390.35 g/mol and does not list a separate amidate SKU at publish time. Match formula and mass on the COA before treating any “Epithalon” label as interchangeable.

What makes an Epithalon COA usable?

A matching lot number, a named laboratory, report identifiers, stated methods and specific results let you assess what was tested. The EPI50312 example above separates purity and identity from a later endotoxin report and provides both PDFs and their printed search codes. Treat each result as specific to its report and submitted sample.

Is this for human use, or for consumer aging or telomere claims?

No. Peptide Foundry supplies Epithalon strictly for laboratory and research use by qualified researchers. Mentions of telomerase enzyme activity or chromosomal telomere measurements in published preclinical and in-vitro literature are pathway-class context only — not product benefits and not human therapy. It is not a drug, supplement, cosmetic finished good, or veterinary product, and not for use in people or animals.

For the current lot certificate and product specifications, see the Epithalon research product page. Related library reading: How to read a research-peptide COA, USA research-peptide vendor criteria, Semax research identity, Lyophilized diluent literacy (BAC vs AA), NAD⁺ research identity, and GHK-Cu research identity.

Research use only. Nothing on this page describes or implies use in humans or animals. Pathway-class mentions of telomerase enzyme activity or telomere measurements refer only to preclinical and in-vitro literature contexts and are not product outcomes.