MOTS-c is a 16-amino-acid mitochondrial-derived peptide (CAS 1627580-64-6). See Peptide Foundry’s formula/mass anchors and the purity panels to demand on a lot COA. Research use only.
- CAS Number
- 1627580-64-6
- Molecular Formula
- C101H152N28O22S2 C101H152N28O22S2
- Molar Mass
- 2174.6 g/mol
MOTS-c is a 16-amino-acid mitochondrial-derived peptide (MDP) — Mitochondrial Open Reading Frame of the 12S rRNA type-c. It is a discrete research material with its own CAS, formula, molar mass, and lot documentation — not a catalogue nickname for every “mitochondrial peptide” listing, and not a synonym for unrelated mitochondrial-targeted research SKUs.
If you found “mots-c,” “mots c peptide,” “mots-c third party tested,” “mots-c coa,” or “mots-c 10mg” in a listing, the useful questions are which registry fields the seller claims, whether the certificate matches those anchors, and how each size option’s lot is documented. Aliases vary; registry fields and certificates do not.
This page covers Peptide Foundry’s published identity anchors, the purity panels a research buyer should demand, worked third-party lots for both live size options, and short pathway-class literacy — then soft-handoffs to the gated MOTS-c research product page. Research use only.
Key points
- MOTS-c = 16-aa mitochondrial-derived peptide (MDP) (Mitochondrial Open Reading Frame of the 12S rRNA type-c); supplied as lyophilized research material.
- Peptide Foundry catalog anchors (live PDP): CAS 1627580-64-6, formula C101H152N28O22S2, molar mass 2174.6 g/mol, PubChem 146675088 — match certificate fields to these claims. Residue count is published; a letter sequence is not listed on the live PDP and is not invented here.
- SKU
PF-MOTS-C; live size options 10 mg and 40 mg lyophilized — each size carries its own lot and certificate; do not conflate panels.- Demand a lot-matched COA: HPLC purity with method/wavelength when stated, identity method, named laboratory, and preferably independent portal verify; “third-party tested” or “high purity” without lot + named lab is unfinished.
- Research use only — not for human or veterinary use.
What is MOTS-c?
MOTS-c is a sixteen-residue mitochondrial-derived peptide (MDP). The name expands to Mitochondrial Open Reading Frame of the 12S rRNA type-c — a naming convention from mitochondrial genetics literature that identifies the open-reading-frame origin, not a product-use story. Residue count is sixteen. The research material on this page is that defined MDP class with the published registry anchors below — not a crude tissue extract and not a brand stack.
A short historical note anchors naming only. Mitochondrial open-reading-frame peptides entered the research literature as a class of mitochondrially encoded short peptides studied in cellular and murine experimental systems. That is origin and naming history — not a catalogue mechanism claim, not registry proof, and not a reason to treat every MDP nickname as interchangeable.
Physical form on research listings is lyophilized solid. Peptide Foundry’s current catalog documents describe lyophilized powder under SKU PF-MOTS-C at 10 mg and 40 mg size options. Appearance is a handling observation — not a purity proof and not a substitute for HPLC or identity data on a certificate.
Market aliases include MOTS-c, MOTS C, MOTSc, and informal “mitochondrial peptide” shorthand. Aliases help search and inventory. They are not identity proof until you have CAS, formula, molar mass, residue count, and a lot-matched certificate that matches the vial size in hand.
Chemical identity anchors
Peptide Foundry publishes a fixed identity set for single-vial MOTS-c. The values below match the live catalog chemistry table at the time of writing. Confirm against the current product page if a lot or chemistry block rotates after publish.
Composition and catalog form
Class: 16-aa mitochondrial-derived peptide (MDP) — Mitochondrial Open Reading Frame of the 12S rRNA type-c. Residue count: 16. SKU PF-MOTS-C; size options on the live listing at publish time: 10 mg and 40 mg lyophilized. The live PDP does not publish a letter amino-acid sequence; this page follows that publication set and does not invent one.
CAS, formula, and molar mass
| Field | Peptide Foundry catalog (live /product/mots-c/) |
|---|---|
| CAS | 1627580-64-6 |
| Formula | C101H152N28O22S2 |
| Molar mass | 2174.6 g/mol |
| PubChem CID | 146675088 |
| Class | 16-aa mitochondrial-derived peptide (MDP) |
| Residues | 16 |
| SKU | PF-MOTS-C |
| Form | Lyophilized |
| Sizes (live options) | 10 mg; 40 mg |
Market pages sometimes round mass differently, omit PubChem, or recycle CAS strings across unrelated mitochondrial nicknames. The practical rule is: match the vendor’s stated CAS + formula + molar mass + residue count to the lot COA, then prefer orthogonal identity (MS / HPLC-RTM) over the nickname alone. Treat each vial size as its own documented lot.
What a MOTS-c COA should show
A certificate of analysis is stronger when it is lot-specific, names the laboratory, states methods, and can be checked outside the supplier’s own site. For the full verification workflow — batch match, named lab, HPLC versus identity, biosafety panels, portal codes — see How to read a research-peptide COA.
Minimum research COA fields
- A lot / batch ID that matches the vial character for character
- Test or report date(s) and a named laboratory
- HPLC purity with method (and wavelength when stated — for example 214 nm)
- An identity method (MS and/or HPLC-RTM)
- Product name / composition consistent with the label and the vendor’s published anchors
- Labeled size that matches the vial (10 mg vs 40 mg are separate documentation tracks)
“Third-party tested,” “high purity MOTS-c,” or “99%+” without a named lab and a lot number is an unfinished claim. A pretty PDF that cannot be tied to the vial in hand is documentation theater. That distinction answers the supplier-intent queries researchers actually type — purity and verification language without inventing a consumer category.
Stronger panels (when claimed)
When a full QC panel is present — the pattern on current Peptide Foundry ILS-tested and Freedom Diagnostics lots — read these as separate analytical results:
- Mass-spectrometry or HPLC-RTM identity confirmation
- Net peptide content versus labeled mass when reported
- Heavy metals by ICP-MS against stated limits
- Sterility / no growth
- Endotoxin (for example USP <85> / LAL)
- Illicit-substance screen (for example fentanyl — not detected)
These describe composition and contamination panels for research documentation. They are not a safety-for-human-use claim, and they do not replace identity or purity.
Worked example — primary lot FO510 (10 mg)
As published on the current Peptide Foundry MOTS-c listing at the time of writing for the 10 mg option:
| Field | Value |
|---|---|
| Lot | FO510 |
| Size | 10 mg |
| Laboratory | ILS Laboratories |
| Received | 07/16/2026 |
| Tested | 07/19/2026 |
| Purity | 99.71% (HPLC @ 214 nm) |
| Net peptide content | 10.72 mg |
| Identity | HPLC-RTM — Pass |
| Fentanyl screen | Not Detected |
| Heavy metals | Pass |
| Sterility | No Growth |
| Endotoxin | NMT 0.05 EU/mL |
| Access code | 767JDD9L |
Cite those figures as Peptide Foundry–published transparency for this lot — not a universal industry floor. Re-verify against the live product panel if the lot rotates after publish.
Three steps that travel with any lot, not just FO510:
- Match the lot number on the vial to the lot on the certificate.
- Confirm CAS, formula, labeled mass, and size option against the certificate and the product label.
- Verify the access code on the issuing laboratory’s own portal (ILS for FO510: access code 767JDD9L) — not only by opening a PDF hosted by the supplier.
Secondary lot FO540 (40 mg) — separate documentation track
The 40 mg size option carries a different lot and a different laboratory panel. Do not paste FO510 figures onto a 40 mg vial, and do not treat the two certificates as interchangeable.
| Field | Value |
|---|---|
| Lot | FO540 |
| Size | 40 mg |
| Laboratory | Freedom Diagnostics |
| Purity | 99.29% (HPLC) |
| Net peptide content | 44.24 mg |
| Access code | Pept2607301334 |
Verify FO540 on Freedom Diagnostics using access code Pept2607301334. Net content 44.24 mg against a 40 mg label is why net peptide content belongs on the checklist separately from purity %. A PDF on a supplier site is a document the supplier controls. A record you can pull from the testing laboratory is not. Portable vendor criteria beyond a single SKU: USA research-peptide vendor criteria.
Historical note only (not current live lots): earlier documentation referenced Chromate lot 35179 and Freedom lot MS312. Those are prior panels — do not cite them as the current FO510 or FO540 certificates.
Related research peers (soft handoffs)
Research catalogues sometimes co-browse cofactor and mitochondrial-adjacent materials beside MDP listings. Co-browsing is inventory adjacency — not a synonym set and not a protocol for combining materials.
- NAD+ research identity — dinucleotide cofactor literacy (not a peptide); useful when buyers confuse storefront taxonomy with chemistry class.
- Epithalon research identity — tetrapeptide identity and COA literacy in the same RUO library voice.
- Optional mitochondrial-targeted peer listing when relevant to catalogue adjacency: SS-31 research product page — match each vial to its own CAS, formula, and lot certificate.
Match each vial to its own registry fields and lot certificate. Shared catalogue adjacency is literacy — not a stack recommendation.
Pathway-class literacy (preclinical / murine framing only)
Mechanism language is useful here only as classification of experimental systems in published literature. It does not establish catalogue-product outcomes in people, and it does not convert a citation into a certificate. Keep this section shorter than identity and COA literacy. Do not treat paper titles as product-use claims.
| Literature class (examples) | Acceptable framing on this page | Not used as product framing |
|---|---|---|
| AMPK-related signaling | Examined in preclinical / murine publications exploring AMPK-pathway endpoints in experimental systems | Consumer metabolic or “AMPK activator” product claims |
| Mitochondria-to-nucleus communication | Studied in models examining mitochondria-to-nucleus signaling components | Human mitochondrial “boost” or wellness product claims |
| Insulin-signaling pathway components | Investigated in murine / cell-system assays of insulin-signaling pathway components | Insulin-resistance therapy or glycemic product claims |
| Lipid-metabolism endpoints | Examined in preclinical work on lipid-metabolism endpoints in experimental systems | Weight-loss, fat-burn, or body-composition product claims |
Human clinical or consumer-facing titles that appear in wider SERPs sit outside the scope of this RUO identity page and are not summarized as product use. Keep pathway class attached to the source paper and the experimental system. Identity remains an analytical question answered by CAS, formula, residue count, and the lot COA.
Storage and lab handling (lyophilized)
Standard laboratory practice for lyophilized synthetic peptides applies:
- Storage. Sealed vials at −20°C, protected from light and moisture. Lyophilized material is substantially more stable than solution.
- Temperature excursions. Brief ambient exposure in transit is normal for lyophilized material. Return vials to −20°C on arrival.
- Freeze–thaw. Minimize repeated freeze–thaw.
- Traceability. Keep the lot number with the material — lot number ties a vial back to its certificate. Keep 10 mg and 40 mg lots distinct in inventory.
Assay-specific handling follows your institution’s SOPs. This page does not publish personal reconstitution schedules or solution-use protocols for MOTS-c. General lyophilized-material diluent literacy (without compound-specific schedules) lives at Lyophilized peptide reconstitution.
Common questions
What is MOTS-c’s CAS, formula, and residue count?
CAS 1627580-64-6; formula C101H152N28O22S2; molar mass 2174.6 g/mol; PubChem CID 146675088; residue count 16 (mitochondrial-derived peptide / MDP). Peptide Foundry catalogs the material as SKU PF-MOTS-C (10 mg and 40 mg lyophilized options at publish time). The live PDP does not publish a letter amino-acid sequence; prefer registry fields over listing nicknames.
What makes a MOTS-c COA usable — and what does “third-party tested” require?
Lot match to the vial, a named laboratory, HPLC purity with method/wavelength when stated, an identity method (MS and/or HPLC-RTM), size consistency with the labeled option, and preferably an independent portal verify path. Stronger documentation adds net peptide content, heavy metals, sterility, endotoxin, and illicit screens when claimed. Worked FO510 figures above — ILS Laboratories, HPLC 99.71% @ 214 nm, HPLC-RTM pass, net 10.72 mg, access code 767JDD9L — and FO540 figures — Freedom Diagnostics, HPLC 99.29%, net 44.24 mg, access Pept2607301334 — are examples of that pattern on Peptide Foundry’s live listing. Do not conflate the two lots. Workflow detail: How to read a research-peptide COA.
Are the 10 mg and 40 mg options the same lot?
No. At publish time the 10 mg option documents lot FO510 (ILS Laboratories; access 767JDD9L) and the 40 mg option documents lot FO540 (Freedom Diagnostics; access Pept2607301334). Match the certificate to the vial size you hold. Prior Chromate / Freedom MS312 panels are historical only and are not current.
Is MOTS-c the same as NAD+ or SS-31?
No. NAD+ is a dinucleotide cofactor, not a peptide. SS-31 is a separate mitochondrial-targeted research material with its own identity anchors. MOTS-c is a 16-aa MDP with CAS 1627580-64-6. Soft peers for literacy: NAD+ research identity, SS-31 research product page. Match each vial to its own certificate.
Is this for weight loss, exercise performance, anti-aging, or human use?
No. Peptide Foundry supplies MOTS-c strictly for laboratory and research use by qualified researchers. Mentions of AMPK-related signaling, mitochondria-to-nucleus communication, insulin-signaling pathway components, or lipid-metabolism endpoints in published preclinical and murine literature are pathway-class context only — not product benefits and not human therapy. This page does not describe consumer finished goods, personal-use schedules, administration protocols, or stack recommendations. MOTS-c here is not a drug, supplement, consumer finished good, or veterinary product, and not for use in people or animals.
For the current lot certificate and product specifications, see the gated MOTS-c research product page. Related library reading: How to read a research-peptide COA, USA research-peptide vendor criteria, Lyophilized peptide reconstitution, NAD+ research identity, and Epithalon research identity.
Research use only. Nothing on this page describes or implies use in humans or animals. Pathway-class mentions of AMPK-related signaling, mitochondria-to-nucleus communication, insulin-signaling pathway components, or lipid-metabolism endpoints refer only to preclinical and murine literature contexts and are not product outcomes.